#MITOZA MEANING SKIN#
(1998) Elaboration of Matrix Metalloproteinase Inhibitors by Human Skin in Organ Culture and by Skin Cells in Monolayer Culture: Relationship to Invasion. (1998) Estrogenes and growth factors induce the mRNA of the 52 K-procathepsin D secreted by breast cancer cells.
American journal of clinical pathology, 119(1): 123-8Ĭavailles, V., Augereau, P., Garcia, M., et al. (2003) Immunohistochemical expression of cathepsin D in meningiomas. (2002) Cathepsin-D affects multiple tumor progression steps in vivo: Proliferation, angiogenesis and apoptosis. The result lead to conlusion that the immunopositivity of Cathepsin D decreases with higher mitosis count and higher tumor grade.īerchem, G., Glondu, M., Gleizes, M., Brouillet, J., Vignon, F., Garcia, M., Liaudet-Coopman, E. A considerable difference was found when the number of mitosis and the histologic tumor grade have been compared with the Cathepsin D immunoexpression. In both primary and recidivant meningioma groups the number of mitosis, as factor tumor agressivness, was counted on 10 and 20 HPF and those results were statistically analyzed. All surgical specimen were evaluated for histologic type of tumor and representative slides were immunostained with the anti-Cathepsin D antibody. We analyzed 50 patients with primary and recidivant intracranial and intraspinal meningiomas who underwent surgery in KBC Zemun during the year 2004, with a two years follow-up. The present study was performed to establish the socioepidemiological caracteristics (mean age, male to female ratio), the prevalence of various histological types of meningiomas in the groups of primary and recidivant tumors as well as Cathepsin D immunoexpression. Rezultati su doveli do zaključka da sa većim brojem mitoza i višim histološkim gradusom tumora, imunopozitivnost Katepsina D opada. Značajna razlika je utvrđena kada je broj mitoza i histološki gradus tumara upoređen sa Katepsin D imunoekspresijom. Kod oba tipa, primarnog i recidivantnog meningeoma, broj mitoza, kao faktor agresivnosti tumora, brojan je na uveličanjima 10x i 20x ( HPF), i ti rezultati su statistički obrađeni. Svi hirurški uzorci su bili procenjeni kao adekvatan histološki tip, a reprezentativni preseci su imuno-obojeni sa anti-Katepsin D antitelima. Analizirali smo 50 pacijenata sa primarnim i recidivantnim, intrakranijalnim i intraspinalnim meningeomima koji su operisani u KBC Zemun -Beograd u toku 2004. Ova studija je izvedena zbog utvrđivanja socioepidemioloških karakteristika (srednja starost, odnos muškaraca i žena), prevalence različitih histoloških tipova meningeoma u grupi primarnih i recidivantnih tumora kao i Katepsin D imunoekspresije.